Mild IVF

 

 

 

 

 

Mild IVF is a type of in vitro fertilisation in which ovarian stimulation is performed with low doses of medication, so that the woman’s natural cycle is respected to a greater extent.

It is indicated for women with low ovarian reserve, cases in which the use of high doses of medication would not generate a greater number of oocytes.

In some cases, it can also be performed in patients with a good prognosis and a high ovarian reserve. It is useful for couples who have difficulty conceiving naturally, helping to overcome both male and female fertility problems.

Mild IVF is IVF where ovarian stimulation is performed by means of a medication that promotes multifollicular development (more than one egg) but in a way that is more respectful of the woman’s natural cycle. This type of stimulation is known as mild stimulation. It is indicated in patients with low ovarian reserve where the use of high doses of medication usually used in conventional stimulation would not generate a greater number of oocytes. Thus, this type of stimulation allows us to obtain the same or better results than conventional cycles with greater comfort for the patients and reducing economic costs.

The process begins with ovarian stimulation by administering low doses of hormones (ovulation inducers and gonadotrophins) for 9-15 days. During this stage, the patient must visit the clinic every 2-3 days for ultrasound monitoring. Once the oocytes reach maturation, they are extracted by ovarian puncture under sedation.

With the recovered oocytes, the laboratory will generate embryos that are cultured until they reach the blastocyst stage, usually 5-6 days after fertilisation. The best quality embryo is selected for transfer to the woman’s uterus. If there are any surplus embryos, they will be frozen for further pregnancy attempts. 

In some cases, such as the genetic study of embryos, all embryos generated are frozen, with the first embryo being transferred in a subsequent cycle. 

STAGES OF THE PROCEDURE
01 Previous Tests

Analysis and semen analysis to assess health and fertility status.

02 Procedure

Treatment preparation visit: Organisation, explanation and planning of the treatment and resolution of doubts.

Ovarian stimulation and follicular controls: Administration of medication for 9-15 days, with ultrasound controls every 2-3 days.

Ovarian puncture: Extraction of the eggs under sedation. Outpatient surgical procedure. The patient can go home 2-3 hours after the procedure.

Embryo generation by IVF.

Embryo culture to blastocyst stage.

Embryo transfer: Transfer of the selected embryo into the uterus. Painless procedure. Freezing of surplus embryos.

Procedure
03 Pregnancy control

Pregnancy test: Approximately 11 days after the transfer, a pregnancy test is carried out by means of a blood test.

Confirmatory ultrasound: If the test is positive, an ultrasound scan is performed at 2 weeks to confirm pregnancy.

Mild IVF is an IVF where ovarian stimulation is performed by means of a medication that enhances multifollicular development but in a way that is more respectful of the woman’s natural cycle.

WHO IS IT FOR?

  • Mild IVF is indicated in patients with low ovarian reserve, where a high dose of medication will not increase the number of available oocytes. This treatment allows for a more economical, comfortable and physiological process without reducing the chances of success.
  • This type of treatment is also suitable for patients with a good prognosis and high ovarian reserve. Fewer surplus embryos are generated, which is ideal for those seeking to have only one child – making the process more body-friendly.

SUCCESS RATES

The clinical gestation rate varies according to the age and specific conditions of the patients, generally between 40-55% per transfer.

The rate decreases with age and other factors that may affect fertility. At older ages, genetic diagnosis of embryos is recommended.

FAQs

It should be assessed on a case-by-case basis. In general, this would not be the medical recommendation. In normal/high ovarian reserve, conventional ovarian stimulation increases the efficiency of the treatment, increasing the chances of pregnancy in a single cycle.

In young women, only in cases of very high ovarian reserve where there is a limited genetic desire (only one child) could we consider mild IVF to reduce the number of surplus embryos.

No. In low ovarian reserve, increasing the hormone dose does not increase the number of oocytes retrieved. Mild IVF facilitates treatment without compromising the chances of success.

Maintaining a healthy diet, taking antioxidants and vitamin supplements, and moderate physical exercise can improve overall health and reduce oxidative stress, benefiting fertility. However, age remains a determining factor in success rates.

Yes, you can lead a normal life, except for a few days before and after the puncture, when it is recommended to avoid sexual intercourse and high-intensity physical exercise. During stimulation, you may experience abdominal distension, breast turgor and/or tiredness.

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