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Endometrial Enrichment
Platelet-rich plasma (PRP) treatment for the endometrium

 

 

 

Platelet Rich Plasma (PRP) treatment for endometrium is an innovative technique aimed primarily at patients with thin endometrium and/or diagnosed with recurrent implantation failure. Its objective is to increase the thickness of the endometrium and/or improve its receptivity in order to favour embryo implantation. 

The process begins with the collection of a blood sample from the patient, from which a platelet-rich plasma fraction is obtained through a specific preparation process. The PRP is then administered to the endometrium in several sessions.

The PRP is prepared in a single day and the sample is kept frozen. Subsequently, the different plasma fractions are thawed and administered during the patient’s endometrial preparation for embryo transfer.

Endometrial PRP treatment aims to increase endometrial thickness and/or quality in patients with thin endometrium and/or a diagnosis of recurrent implantation failure. This treatment is especially aimed at patients in whom an adequate endometrial thickness is not achieved despite having applied different oestrogen administration protocols and/or in those patients who have undergone several good quality embryo transfers without resulting in pregnancy.

Once established that the woman qualifies for endometrial PRP treatment, she is scheduled for preparation, which consists of a peripheral blood draw. This blood sample will be processed according to a standardised protocol to separate the platelet-rich plasma fraction from the rest of the blood components and frozen in different fractions (the total number may vary depending on the total volume of plasma obtained).

Afterwards, the patient will start the endometrial preparation for the embryo transfer according to the protocol determined by her doctor. During this same process, and taking advantage of the visits for ultrasound checks, the PRP will be administered at endometrial level as in an artificial insemination (AI) procedure. The patient will be placed in gynaecological position in the consultation room, a speculum will be used to visualise the cervix and, using an AI catheter, a previously thawed fraction of PRP will be introduced. This procedure does not require anaesthesia and is repeated a total of 3 times. From this point on, when the doctor considers the patient ready, the embryo transfer is scheduled according to the established protocol.

Bear in mind that, as this is a technique that uses biological material obtained from the patient herself, it is considered to have a very low risk of adverse effects. It should also be noted that, although an increase in endometrial thickness is not always achieved, the best results observed in patients with the aforementioned pathologies are thought to be due to a qualitative improvement at the molecular level in the endometrium.

STAGES OF THE PROCEDURE
01 Previous Tests

Tests that the doctor deems appropriate must be completed before treatment can begin.

02 Procedure

Treatment preparation visit: Organisation and explanation of the cycle and resolution of doubts.

Blood collection: Blood collection is scheduled to prepare the PRP at any time during the menstrual cycle.

Start of endometrial preparation according to protocol.

Administration of PRP fractions coinciding with ultrasound checks up to a total of 3 sessions.

Procedure

Platelet Rich Plasma (PRP) treatment for endometrium is an innovative technique aimed primarily at patients with thin endometrium and/or a diagnosis of recurrent implantation failure.

WHO IS IT FOR?

  • For patients with thin endometrium and/or recurrent implantation failure.

SUCCESS RATES

As this is a relatively recent technique and intended for very specific cases, there is insufficient data to provide representative success rates.

FAQs

At this time it is not possible to guarantee that the application of PRP to the endometrium will improve reproductive outcomes.

Ovarian and endometrial PRP are two different techniques based on the same principle: applying the potential of growth factors present in plasma. However, the potential and expected effects vary substantially depending on the tissue where they are applied and therefore, they cannot be considered the same technique.

 

The material used in endometrial PRP treatment comes from the person receiving it, so the risk of adverse effects is very low. In addition, the treatment being similar to artificial insemination in terms of its execution, the risk of suffering complications is minimal.

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