IVF with Smart PGT-SR Plus
Preimplantational Genetic Test for structural rearrangements

 

 

 

IVF with preimplantation genetic study of structural rearrangements (or PGT-SR) is an assisted reproductive technique that genetically analyses embryos before transfer.

It helps to select healthy embryos, which improves the chances of evolutionary pregnancy.

It is indicated for people with a chromosomal rearrangement in the karyotype.

It has a success rate of 60-70% per transfer.

In this assisted reproduction treatment, embryos are created and undergo genetic analysis to check for any chromosomal abnormalities. This is done by IVF treatment, which involves stimulation of the ovaries and subsequent egg retrieval. The eggs are fertilised in the laboratory and the resulting embryos are cultured until they reach the blastocyst stage. At this point, a biopsy is performed to study their genetic make-up.

When a chromosomally normal (euploid) embryo is obtained, the uterus is prepared for embryo transfer. If the embryo is euploid, the chances of pregnancy by transfer are 60-70%. However, in cases such as advanced maternal age or low ovarian reserve, obtaining a healthy embryo may be more difficult, so the doctor may recommend cumulating several embryos.

At Fertty we use Smart PGT-SR Plus technology, which provides more detailed information than other testing methods. It detects alterations in chromosome number, but also if there is an extra or missing set of chromosomes (known as ploidy alteration). In addition, this analysis is able to detect possible contaminations in the samples and confirm kinship of the embryos, which provides extra security and accuracy in the results.

STAGES OF THE PROCEDURE
01 Previous Tests

Tests that the doctor deems appropriate must be completed before treatment can begin. These are usually analysis and seminogram (if applicable). 

 

02 Procedure

Treatment preparation visit: Organisation and explanation of the cycle, resolution of doubts and medication schedule for ovarian stimulation.

Ovarian stimulation: For 10-12 days, the woman must take the prescribed medication and attend the necessary ultrasound check-ups in order to obtain the maximum number of oocytes for that cycle.

Ovarian puncture: Egg retrieval under sedation.

Generation of embryos by IVF and embryo culture up to the blastocyst stage.

Embryo biopsy: Obtaining the embryo cells necessary for the genetic study. After biopsy, the embryos are be vitrified while awaiting the results of the study.

Result of the genetic study: Information is provided on the chromosomal endowment of the embryo. If an euploid embryo (chromosomally normal or balanced) is obtained, we will move on to the next stage. If not, treatment must be repeated or therapeutic strategy must be changed.

Endometrial preparation: The preparation of the endometrium (inner layer of the uterus) for the transfer begins with the period and will again require several gynaecological ultrasound scans. Medication may be required and will be prescribed by your doctor.

Embryo transfer: When the endometrium is prepared, the embryo transfer takes place. On this day, the embryo reported as euploid is thawed and, by means of an ultrasound-guided procedure, the embryo is positioned in the most suitable place in the uterus for implantation. 

Procedure
03 Gestational Control

Pregnancy test: Approximately 11 days after the transfer, a pregnancy test is performed to show whether the patient is pregnant or not.

Confirmation ultrasound: If the pregnancy test is positive, an ultrasound scan is carried out after 2 weeks to confirm that the pregnancy is proceeding correctly.

IVF with preimplantation genetic study of structural rearrangements is an assisted reproduction technique that genetically analyzes embryos prior to transfer.

 

WHO IS IT FOR?

In some circumstances in reproduction, the risk of genetic abnormality of the embryo may be higher. One of them is that one of the parents carries a balanced structural alteration in the karyotype, such as a translocation or a chromosomal inversion; in this case, there is an exchange of material between chromosomes or within the same chromosome. This may result in errors in the segregation of genetic material at the time of gamete formation, leading to the formation of unbalanced gametes and, consequently, unbalanced embryos. This is the main cause of repeated miscarriages.

SUCCESS RATES

In the cases in which pre-implantation genetic diagnosis of the embryos was carried out, the rate of pregnancy in the first transfer was 67.4%. This clinical pregnancy rate in the first transfer was 68.4% in women aged 35 or under, 66.7% in women aged between 36 and 39 and 67% in women aged 40 or over.

FAQs

Yes, you can lead a normal life during treatment, except for a few days before and after the puncture. You cannot have sexual relations or engage in high-intensity physical exercise. Ovarian stimulation is a treatment that is very well tolerated by patients. During this process, you may experience abdominal distension, breast turgor and/or a certain degree of tiredness. On the day of the egg retrieval (ovarian puncture) you will have to rest and will not be able to work.

Depending on your characteristics, mainly your ovarian reserve and your age, it may be necessary to obtain more eggs than your ovary produces in a single stimulation cycle in order to obtain a genetically normal embryo. Consult our doctors and biologists for your particular statistics.

Ovarian freezing techniques have improved a lot in recent times. Currently, ultra-rapid freezing techniques are used which allow us to have a 98% survival rate on thawing.

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