IN VITRO FERTILISATION WITH PREIMPLANTATION GENETIC SCREENING (PGT-A)
Selection of embryos free of genetic diseases and chromosomal alterations before implantation in IVF with PGT-A.
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What is it?
PGT-A is a Preimplantational Genetic Screening for the detection of aneuploidy.
We call aneuploidies those alterations in the total number of chromosomes of the biopsied embryo. With PGT-A, the DNA of the embryos is studied in order to select those with a correct and balanced genetic load. Some chromosomal abnormalities compromise the viability of the embryo (non-implantation or miscarriage), others may result in a genetic disease in the future baby.
For whom is it recommended?
At Fertty we are committed to the health of both mothers and babies born thanks to advanced assisted reproduction techniques.
For this reason, it is recommended in the following cases:
Maternal age over 35
Maternal age over 35, because as the age of the mother-to-be increases, the quality of the eggs decreases, and the risk of producing an embryo with chromosomal abnormalities increases.
In men with altered seminogram parameters
In men with altered seminogram parameters, as this may indicate an aneuploidy in the spermatozoa.
Following two miscarriages.
Couples who have had previous IVF cycle failures.
Patients who wish to perform future cryopreserved embryo transfers in case of failure in a first attempt.
Couples with a family history of chromosomal problems.
Couples with previous pregnancies with altered chromosome number.
Couples carrying numerical abnormalities for the sex chromosomes (X or Y).
Cases of cryopreserved semen samples vasectomized or successfully submitted to radio or chemotherapy treatment.
Procedure
Step 1:
Following an IVF cycle, and before the transfer of the blastocyst to the mother’s uterus, our embryologists extract a small number of cells from the outer layer of each embryo (its future placenta) by means of an embryo biopsy and process these cells for genetic analysis. On the same day, the embryos are vitrified in the clinic’s laboratory.
Step 2:
The generic laboratory analyses the chromosomal endowment of each embryo to select those with the correct number of chromosomes. Biopsy results are usually available after about 10 days.
Step 3:
Once our specialists have analysed the results of the biopsy and know which of the embryos will be suitable for transfer, they will proceed with the thawing of one of them and transfer it to the mother’s uterus. The rest of the biopsied and selected embryos will be frozen for possible future use.
Implantation with this process increases the chances of pregnancy, decreases the chances of miscarriage and allows the development of a healthy child.
IN VITRO
FERTILISATION
WITH DGP OR PGS
IT INCLUDES
- First consultation and personalised monitoring of all medical processes
- Egg retrieval, operating theatre and anaesthesia
- Preparation of the sperm sample
- Oocyte Fertilisation – IVF / ICSI
- Trophoctoderm biopsy and preparation of cellular material
- Freezing of embryos
- Subsequent endometrial preparation
- Thawing of embryos 1st
- Embryo transfer
- Pregnancy test β-hCG and 1st pregnancy ultrasound scan
NOT INCLUDED
- Second consultation
- COVID 19 Antigen Test
- PCR SARS COVID 19
- Medication for ovarian stimulation, endometrial preparation and pre-analyses
- Embryo culture
- Annual maintenance fee frozen supernumerary euploid frozen embryos
- Sedation during embryo transfer
- Sperm bank
- Sperm bank + matching
- Sperm freezing
- Genetic Compatibility Test (GCT)
- NGS genetic analysis for each embryo (until 6 embryos)
- Analysis of more than 6 embryos (total)
- Treatment for successive cryopreserved embryo transfers